

Sumalee Montano as Nila, a firbolg druid whose husband and son were taken by the Iron Shepherds.Ashly Burch as Keg, a dwarven fighter who joins the party in the fight against the Iron Shepherds.Mark Hulmes as Calianna, a half- elf sorcerer who enlists the party to help her find and destroy an artefact.Khary Payton as Shakäste, a human cleric who aids the party as they investigate a gnoll attack in Alfield.Though he plays a different character, Chris Perkins is the only guest player who also appeared in Campaign 1. There were seven guest players for Campaign 2. She is returned to her halfling body in episode 97 and comes to struggle with her conflicting desires to continue adventuring with the Mighty Nein and to stay with her husband and child. She was previously a halfling woman named Veth Brenatto who was cursed to be a goblin following her family's capture by a goblin raiding party. Sam Riegel as Nott the Brave, a goblin rogue who escaped a jail with Caleb and wishes to support his growing magical potential.Initially presented as resentful of authority and anti-social, she rises to the rank of Expositor to carry out sensitive and covert investigations. Marisha Ray as Beauregard "Beau" Lionett, a human monk working for the Order of the Cobalt Soul to root out corruption in the Dwendalian Empire.Taliesin Jaffe as Mollymauk "Molly" Tealeaf from episodes 1 to 26, a tiefling blood hunter and con artist working in a traveling circus and from episode 28 onward as Caduceus Clay, a firbolg cleric in service of the Wildmother, goddess of wilderness, who is searching for a way to save his home from a magical blight.

Caleb is also known for inventing spells.

This training proved to be physically and mentally traumatising, leading to a breakdown.
